IPIX Maintains Presence in Oak Ridge

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RESTON, Va. – Nov. 21, 2005 – IPIX Corporation (NASDAQ: IPIX) today stated that it would continue operations in Oak Ridge, Tennessee. The clarification follows the announcement last week that IPIX is taking cost cutting measures that will help the company conserve its cash resources, minimize operational redundancies and align internal resources to take full advantage of the growing demand for immersive technology solutions.

"Our remaining staff in Oak Ridge will continue to be instrumental in the growth of our business and allow the company to effectively address new and existing clients," said Clara Conti, IPIX chief executive officer and president. "As demand for our technology continues to grow, we fully expect that our Tennessee staff will as well."

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About IPIX

IPIX Corporation is a premium provider of immersive imaging products for government and commercial applications. We combine experience, patented technology and strategic partnerships to deliver visual intelligence solutions worldwide. Our immersive, 360-degree imaging technology has been used to create high-resolution digital still photography and video products for surveillance, visual documentation and forensic analysis. www.ipix.com

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This press release may contain forward-looking information within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the safe harbors under those sections. In some cases, you can identify forward-looking statements by terminology such as "expect," "believe," "may," "will," "plans" and "anticipate," or the negative of such terms or comparable terminology. Forward-looking statements appearing herein include statements concerning operating and profitability plans and goals and restructuring efforts and are based on current expectations.

Actual results may differ materially from those projected in the forward-looking statements based upon a number of factors including: changes in the demand for our products and services; our third-party supplier's ability to deliver high quality components to us in a timely fashion; our ability to control or effect reductions in costs; uncertainty regarding our ability to continue as a going concern; our ability to raise capital and fund our operations; our ability to attract and retain highly qualified personnel; our ability to design, manufacture and deliver high quality products in a timely fashion; and, the burdens and costs of defending against potential infringement claims.

The matters discussed in this press release also involve risks and uncertainties described from time to time in documents filed with the Securities and Exchange Commission, including but not limited to Form 10-Ks, Form 10-K/As, Form 10-Qs, Form S-3s and Form 8-Ks (www.sec.gov).

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IPIX Media Contact

(202) 478-3563